SorLA (SORL1) Mouse Monoclonal Antibody [Clone ID: 3B6B11]

SKU AM06185SU-N

SorLA (SORL1) mouse monoclonal antibody, clone 3B6B11, Ascites

Product Data

• Clone Name: 3B6B11
• Application: FC, IF, IHC, WB
• Recommended Dilution: ELISA: 1/10000.; Western Bloting: 1/500-1/2000.; Immunofluorescence: 1/200-1/1000.; Immunohistochemistry on Frozen Sections: 1/200-1/1000.; Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of Human SORL1 expressed in E. Coli.
• Specificity: Recognizes Sortilin-related receptor (SORL1)
• Buffer: State: Ascites; State: Ascitic fluid; Preservative: 0.03% Sodium Azide
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Gene Name: sortilin-related receptor, L(DLR class) A repeats containing
• Database Link:
  Q92673
• Background: SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
• Synonyms: SorLA, SorLA-1, LR11

Reference Data