FES Mouse Monoclonal Antibody [Clone ID: 2E3G3]

SKU AM06182SU-N

FES mouse monoclonal antibody, clone 2E3G3, Ascites

Product Data

• Clone Name: 2E3G3
• Application: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.; Western Bloting: 1/500 - 1/2000.; Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of FES expressed in E. Coli.
• Specificity: Recognizes FES (Feline Sarcoma Oncogene).
• Buffer: State: Ascites; State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Gene Name: FES proto-oncogene, tyrosine kinase
• Database Link:
  P07332
• Background: FES (Feline Sarcoma Oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.
• Synonyms: FES, FPS, Proto-oncogene c-Fps

Reference Data