KAT8 Mouse Monoclonal Antibody [Clone ID: 8C4C4]

SKU AM06177SU-N

KAT8 mouse monoclonal antibody, clone 8C4C4, Ascites

Product Data

• Clone Name: 8C4C4
• Application: IF, IHC, WB
• Recommended Dilution: ELISA: 1/10000.; Western Bloting: 1/500 - 1/2000.; Immunofluorescence: 1/200 - 1/1000. ; Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of human MYST1 expressed in E. Coli.
• Specificity: Recognizes MYST1
• Buffer: State: Ascites; State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Predicted Protein Size: 53 kDa
• Gene Name: lysine acetyltransferase 8
• Database Link:
  Q9H7Z6
• Background: MYST1 (MYST histone acetyltransferase 1, MOF) belongs to the MYST family of histone acetyltransferases, which are employed in the cell to bring about transcriptional regulation. The MYST family includes MYST1, is named for the founding members MOZ, yeast YBF2 and SAS2, and TIP60. All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein- protein interactions and targeting transcriptional regulators to chromatin. Although MOF is expressed in both males and females, it associates with the X chromosome only in males. MOF contains a zinc-finger domain that is used to contact the globular part of the nucleosome and histone H4. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone
• Synonyms: MOF, PP7073, YBF2/SAS3, SAS2, TIP60 protein 1, HMOF

Reference Data