Complement C7 (C7) Mouse Monoclonal Antibody [Clone ID: 030-113.7.5.4]

CAT#: AM05623PU-N

Complement C7 (C7) mouse monoclonal antibody, clone 030-113.7.5.4, Purified

Specifications

Product Data

• Clone Name: 030-113.7.5.4
• Applications: ELISA, FN, WB
• Recommended Dilution: ELISA.
  Western Blot.
  Functional Assays: Removal of Sodium Azide is recommended prior to use.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified human C7
• Specificity: This antibody recognises complement component 7 (C7), a 110 kDa glycoprotein present in the blood serum. Note that this antibody does not recognise membrane bound complement membrane attack complex. This antibody inhibits lysis of sensitised sheep erythrocytes.
• Formulation: Borate buffered saline pH8.2 - 8.4 containing 0.02% Sodium Azide (NaN3)
  State: Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: complement component 7
• Database Link:
  Entrez Gene 730 Human
  UniProt ID P10643
• Background: The factor I domain of C7 binds the C terminus of the C5 alpha-chain, acting as a membrane anchor. This enables the assembly of the complement membrane attack complex (MAC) and consequent complement lytic activity. C7 deficiency is associated with increased susceptibility to recurrent infections, in particular by Neisseria meningitides.
• Synonyms: Complement component C7, Complement 7

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus