Alkaline Phosphatase (ALPL) (NM_000478) Human Recombinant Protein

CAT#: TP305692

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Recombinant protein of human alkaline phosphatase, liver/bone/kidney (ALPL), transcript variant 1


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USD 748.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human alkaline phosphatase, liver/bone/kidney (ALPL), transcript variant 1
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 55.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000469
Locus ID 249
Refseq Size 2606
Cytogenetics 1p36.12
Refseq ORF 1572
Synonyms AP-TNAP; APTNAP; HOPS; TNALP; TNAP; TNSALP
Summary This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Protein Families Druggable Genome
Protein Pathways Folate biosynthesis, Metabolic pathways

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