Alkaline Phosphatase (ALPL) (NM_000478) Human Recombinant Protein

CAT#: TP305692

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Recombinant protein of human alkaline phosphatase, liver/bone/kidney (ALPL), transcript variant 1



  View other "ALPL" proteins (9)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human alkaline phosphatase, liver/bone/kidney (ALPL), transcript variant 1
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC205692. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 55.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000469
Locus ID 249
Refseq Size 2606
Cytogenetics 1p36.12
Refseq ORF 1572
Synonyms AP-TNAP; APTNAP; HOPS; TNALP; TNAP; TNSALP
Summary This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Protein Families Druggable Genome
Protein Pathways Folate biosynthesis, Metabolic pathways

Citations (1)

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