ErbB 3 (ERBB3) (NM_001005915) Human Mass Spec Standard

CAT#: PH324398

ERBB3 MS Standard C13 and N15-labeled recombinant protein (NP_001005915)

  View other "ERBB3" proteins (16)

USD 1,995.00


Availability*
3 Weeks

Size
    • 10 ug


Product images

Specifications

Product Data
Description ERBB3 MS Standard C13 and N15-labeled recombinant protein (NP_001005915)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC224398
Predicted MW 20.17 kDa
Protein Sequence
Tag C-MYC/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80°C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_001005915
RefSeq Size 1050
RefSeq ORF 549
Synonyms c-erbB-3; c-erbB3; ErbB-3; erbB3-S; HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3
Locus ID 2065
Cytogenetics 12q13.2
Summary This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Documents

Other Versions

Other products for "ERBB3"
Frequently bought together (2)
Transient overexpression lysate of v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant s
    • 100 ug

USD 315.00


ERBB3 mouse monoclonal antibody, clone OTI3E10 (formerly 3E10)
    • 100 ul

USD 360.00

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
40% off proteins and antibodies
68 Mouse Clones