MTOR (NM_004958) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC220457L1V

  • LentiORF®

Lenti ORF particles, MTOR (Myc-DDK tagged) - Human mechanistic target of rapamycin (serine/threonine kinase) (MTOR), 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP


Buy this product and get 50% off on the Lenti RapidTiter kit. Use Code: Rapid50

USD 3,705.00

2 Weeks*

Size
    • 200 ul

Product Images

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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Symbol MTOR
Synonyms FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS
Mammalian Cell Selection None
Vector pLenti-C-Myc-DDK
ACCN NM_004958
ORF Size 7647 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC220457).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_004958.2
RefSeq Size 8680 bp
RefSeq ORF 7650 bp
Locus ID 2475
UniProt ID P42345
Cytogenetics 1p36.22
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Acute myeloid leukemia, Adipocytokine signaling pathway, ErbB signaling pathway, Glioma, Insulin signaling pathway, mTOR signaling pathway, Pathways in cancer, Prostate cancer, Type II diabetes mellitus
MW 288.7 kDa
Gene Summary The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.