APE1 (APEX1) (NM_001641) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC201732L2V

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  • LentiORF®

Lenti ORF particles, APEX1 (mGFP-tagged) - Human APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1, 200ul, >10^7 TU/mL



USD 850.00


Availability*
6 Weeks

Size
    • 200 ul


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Specifications

Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Symbol APEX1
Synonyms APE; APE1; APEN; APEX; APX; HAP1; REF1
Mammalian Cell Selection None
Vector pLenti-C-mGFP
ACCN NM_001641
ORF Size 954 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC201732).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_001641.2
RefSeq Size 1574 bp
RefSeq ORF 957 bp
Locus ID 328
UniProt ID P27695
Cytogenetics 14q11.2
Domains Exo_endo_phos
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Base excision repair
MW 35.4 kDa
Gene Summary The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.[provided by RefSeq, Dec 2019]
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