Neuraminidase (NEU1) (NM_000434) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200386L2V

Lenti ORF particles, NEU1 (mGFP-tagged) - Human sialidase 1 (lysosomal sialidase) (NEU1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: Neuraminidase
• Synonyms: NANH; NEU; SIAL1
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_000434
• ORF Size: 1245 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200386).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000434.2
• RefSeq Size: 2088 bp
• RefSeq ORF: 1248 bp
• Locus ID: 4758
• UniProt ID: Q99519
• Cytogenetics: 6p21.33
• Domains: BNR
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome, Other glycan degradation, Sphingolipid metabolism
• MW: 45.5 kDa
• Gene Summary: The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]