Thyroid Hormone Receptor beta(THRB) (NM_000461) Human Untagged Clone
THRB (untagged)-Human thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) (THRB), transcript variant 1
|Product Name||Thyroid Hormone Receptor beta(THRB) (NM_000461) Human Untagged Clone|
|Synonyms||C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2; PRTH; THR1; THRB1; THRB2|
Fully Sequenced ORF
>OriGene ORF sequence for NM_000461 edited
5' Read Nucleotide Sequence
>OriGene 5' read for NM_000461 unedited
|ORF Size||1386 bp|
|OTI Disclaimer||Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at email@example.com or by calling 301.340.3188 option 3 for pricing and delivery.
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Protein Families||Nuclear Hormone Receptor, Transcription Factors, Druggable Genome|
|Protein Pathways||Neuroactive ligand-receptor interaction|
|Gene Summary||The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2, 3 and 4 encode the same protein.
|The use of this cDNA Clones has been cited in the following citations:|
Transient Maternal Hypothyroxinemia Potentiates the Transcriptional Response to Exogenous Thyroid Hormone in the Fetal Cerebral Cortex Before the Onset of Fetal Thyroid Function: A Messenger and MicroRNA Profiling Study
,Dong, H;You, SH;Williams, A;Wade, MG;Yauk, CL;Thomas Zoeller, R;,
Cereb. Cortex, Jan 2014.,PubMed ID 24436321
Novel mechanism of positive versus negative regulation by thyroid hormone receptor beta 1 (TRß1) identified by genome-wide profiling of binding sites in mouse liver
,Ramadoss, P;Abraham, BJ;Tsai, L;Zhou, Y;Costa-E-Sousa, RH;Ye, F;Bilban, M;Zhao, K;Hollenberg, AN;,
J. Biol. Chem. Nov 2013,PubMed ID 24288132
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