C2cd2l (NM_027909) Mouse Untagged Clone

CAT#: MC202622

C2cd2l (untagged) - Mouse C2 calcium-dependent domain containing 2-like (C2cd2l), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: C2cd2l
• Synonyms: 1300006O23Rik; Tmem24
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC060156 sequence for NM_027909
  GGAACCTAGCTGGGGTCACACCGCCGGTGTTAGGGATCCAGATCTCTGGCTACGGAGACAGAGCTCGAGC GTCGCGACCCCGGAGGACCTCTTCTCCATCCGTGGCACCCACTGGTCCTGGAATCTCGGCGGCGCCGGAG AGCCCCGGAGCCCGCGCGCTCAGCCCCGGGGGAGCTCGCCCACGCCCCACGGTCCATCCGGGCCATGCTC CCCCGGGGCAGCGGCTGAACCCGAGCCGGGACCCGAGCCCGCGGGAGCATGGATCCGGACTGGGGGCAGC GGGATGTGGGCTGGGCGGCCCTGCTGGTTCTCTTCGCCGCCTCGCTGATCACGGTATTGGGCTGGATGCT GCAGTATGCCCGGGGTTTGTGGCTGTCGCGAGCCGATGGGGGCCGAGACTCCCGACCTGCCTCAGCTGCT GAGCCCGGGGGTTCACTGCGCGAGCTGGGTGTGTGGCGTTCGCTGCTGCGTTTGCGGGCGACCCGGACCA GCACCCCCGAGGAAGCCGGCGTACGGGGCCTCCTGGCTTCGCTCTTTGCCTTCAAGTCTTTCCGGGAGAA CTGGCAACGGGCTTGGGTGCGAGCCTTGAATGAGCAGGCCTGCAGGGACGGGAGCTCCATCCAAATCGCC TTTGAAGAGATACCCCAACTCCCACCAAGAGCCAGCATCAGTCATGTGACCTGCGTTGACCAATCAGAGC GCACCATGGTGCTGCATTGCCAGCTCTCTGCTGAGGAGGTGCGCTTCCCCATCTCTGTGACCCAGCAGTC CCCCGCTGCCGTCTCCATGGAGACCTACCACGTCACTCTGACACTGCCACCAACACAGTTGGAAGTCAGC CTGGAGGAAATCCCTGATGAGGGGCTCCTGGTGTCCTGGGCCTTCACTGACCGCCCAGAACTCAGCCTAA AGGTGCTTCCCAAGTTGCAGACTAGGGAGAGAGATGAGGAACAACCAGAGCTCTCAACAGTTGAGGAACT GATCAAGGACGCTATAGTCAGCACTCAGCCCGCCATGATGGTCAACCTCAGGGCCTGCTCTGCCCCAGGA GGCCTGGTACCCAGTGAGAAGCCACCCACGATGTCCCAGGCCCAGCCATCCATCCCCAGACCTACCCGAT TATTCTTACGGCAGCTTCGAGCATCTCACCTGGGAAGTGAGCTAGGAGGTACTGAGGAACTGTGCTGTGC CGCTGAGCTTGACAACCCCATGCAACAAAAGTGGACCAAACCCATGAGGGCGGGCCCCGAGGTGGAATGG ACCGAGGACCTAGCTCTGGATCTGGGTCCCCAGAGCCGGGAGCTGACCCTCAAAGTGCTCCGGAGCAGCA GCTGTGGAGATGCTGAACTCCTTGGCCAAGCCACACTGCCTGTGGGCTCACCCTCTAGACCGATGTCACG AAGACAGGTGTGCCCACTGACTCCAGGGCCCGGGAAATCCCTGAGCCCGGCAGCCACCGTGACAGCGGAG CTACATTATGAGCAGGGTTCCCCTCGGAATCTGGGCACGCCCACCTCCTCCACCCCTCGCCCCAGCATCA CACCCACCAAGAAGATTGAGTTGGACCGGACCATCATGCCCGACGGCACAGTCGTCACCACTGTCACTAC CGTCCAGTCCCGCCCCCGTGTAGATGGCAAACTAGACTCCCCCTCCCGCTCCCCGTCCAAGGTGGAGGTG ACTGAGAAGATGACAACCGTGCTGAGTGAGAGCAGCGGCCCCAGCAATGCCTCCCACAGCAGCAGCCGGG AGAGCCACCTTTCCAATGGCTTGGATCCAGTAGCAGAGACAGCCATTCGCCAGCTGACTGAGCCCAGTGG GCGGGCAGCCAAGAAGACACCCACCAAGAGGAGCACGCTCATCATCTCTGGTGTTTCCAAGGTGCCCATC GCCCAGGACGAGTTGGTTCTCTCCTTGGGTTACGCGGCATCTCTGGAAGCCTCGATGCAAGATGATGCAG GAACCAGTGGTGGTCCTTCGTCACCTCCCTCAGACCCCTCAGCCACATCCCCAGGACCTGTTGATGCCCT CTCCAGTCCCACAAGTGTCCAGGAGGCAGATGAGACAACACGTTCAGACATCTCTGAGAGGCCGTCTGTG GATGATGTTGAGTCAGAAACAGGGTCCACTGGTGCCCTGGAGACCAGAAGCCTCAAGGATCACAAAGTGA GTTTCCTGCGCAGTGGCACAAAGCTCATCTTCCGCCGGAGGCCCCGACAGAAGGAAGCTGGTCTGAGCCA GTCACACGATGACCTGTCCAACACGACGGCCACACCTAGCGTCCGGAAGAAGGCTGGCAGCTTTTCCCGT CGCCTTATCAAGCGTTTTTCCTTCAAATCCAAACCCAAGGCCAATGGCAACCCTAGCCCCCAGCTCTGAA AGCCCCCGAGCTAGGAGAGATCAAGAGTTCTCTTAGTCTGTCCCCCACATCCCCTTCTGTACCCCTTCCT GGATCCCCACTGCTGGGGCCAGGAAAGCCCTCGGGTTATAGGGAGCCCCAGCACACTGGGCTGTGGGGTG AGCGGGAAGGGTGTCTGACATGGGAGGCATCTGGGAGGCAACAGTTGTTGCGTGAGCGTAGAGGAGAGTT TGGCAGCTGAGAGTCAGGGGCAAGCTCTGTCTTGGGCGTGTGGACACTCATCAGAAGCCTCTGCTGGTAC TGCCGCCAGAGGGGAGCCCAGAGTACTCTCTCATCAGCAGGTCCTTCTCCCTTATTTATTCTCGTTTCTA TTTATATGTGTGGTCTAGAACCCTTGGCAAACAGATGATAGAGGGCATCTCTCCCAGGTGACCCTTTTCT GTCCCAGGAGGGTAAGGCAATTCCCAGGACGGGTTTCTACCCCTCCCTTGGGAGTCCTCTCTTAGACCAG CACCAATGTCTGCCTTCAGAAGACATTGGCAGATCACAGGAAGCCGGGCTAGGGCCCGGGATGGGGGGCA GGCACTCCCCACCTCCCTACCTCCCACATCGCTCCTTGTCTCTCCTTCCCCTTTATTACCATTTTGTACT TGATGCCTTCTCCATGAGCAGTGGCTCAGTTGGAAGGAGGGAGCCAGGAAGCTGGGAGGAAGCCTTCCCT AGAGAGCCAGCTTTAGGAGTTTTAAAGACAGTACGATCATAGAGCAAGGTTGCACCTCTGTATGTTGGGA GATGATGATGTCCATTGCTGTGTGATGGCCTGGAATTTAATTTATTTAATTAAAATCAAATTGGAGTTTA AAAAAAAAAAAAAAAAA
• Restriction Sites: AscI-NotI
• ACCN: NM_027909
• Insert Size: 2121 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC060156, AAH60156
• RefSeq Size: 3237 bp
• RefSeq ORF: 2121 bp
• Locus ID: 71764
• UniProt ID: Q80X80
• Cytogenetics: 9 A5.2
• Gene Summary: Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (By similarity). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (By similarity). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (By similarity). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (By similarity). Positively regulates insulin secretion in response to glucose (PubMed:24012759). Phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (By similarity).[UniProtKB/Swiss-Prot Function]