RASGRP 4 (RASGRP4) (NM_001146203) Human 3' UTR Clone
CAT#: SC211705
3' UTR clone of RAS guanyl releasing protein 4 (RASGRP4) transcript variant c for miRNA target validation
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Specifications
Product Data | |
Vector | pMirTarget |
Species | Human |
Transfection Reporter | RFP |
Assay Reporter | Luciferase |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Symbol | RASGRP4 |
ACCN | NM_001146203 |
Insert Size | 1012 bp |
Sequence Data |
>SC211705 3’UTR clone of NM_001146203
The sequence shown below is from the reference sequence of NM_001146203. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCAACTGCATCCTCCAAGCTGGATTCCTAGACATCTCTTGGTCTCCTCTCTTCCTCACTCCCTTCCCCC AGTCAGTCCTGAGTCCTGCCGTCAGACTCTGGCAGGGCTCCCAGAGGTAGGCCTCCAGAGGCATCCGCC TTCCCATCCACACTGCCTTTAGTGGTACGTCCGTCATCTTTTTCCCTGGAAGTGACTTTCCTCTTTTGC ATCCTGGTGGATGCTAATCCTGCTCCCTTTCCCTGCACTTAGTATCTGTGCGGCTGTGTGTTGGATACA TTTAGACTCAGGCCTCATTCTACCAACTCCCTACATCTCCATTTCTTTTTTTTTTTGAGACAGAGTCTT GCTCTGTCACCCAGGCTGGAGTGCAATGATGCAATCTCAGCTCACTGCAACTTCCGCCTCCTGGGTTCA AGTGATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACGCGCCACCATGCCCGGCTAATT TTTGTATTTTTAGTAGAGACGGGGTTTCCCCATGTTGGCCAAGATGGTCTCAAACTCCTGACCTCATGA TCCACCAGCCTCAGCCTCCCAAAGTGCTGGGAATACAGGCGTGAGCCACCACGCCCAGCTCCTGTTTTT CTGCATAGAATGTGCTCCCTCTGACAGCCTATACTTTTTCCCTCTTTATCTCGTTGAACGTCTGTCTTT CCTCAACAGGAGCATCAACTCCAGGAGAACAGGGATTTCTATCAATGTCATTCACTGCTGCATCCCCAG TGCCTAGAACAGGGCTGGCAGGTGGTAGGCGCCTGACAGATGCTTGTCTGATGCCTGAATGTCTCCTTA CCCATGCCCACGGCACAGGATAGATGTGCTATAGGGCAAAGAACTTTGAGGGTCGAGCAGCAGGGGCCC ATTCAGTCCCAGGGAGCAGAGACCCCCCCAACCCCTTCACAAACCCCAACACCCCTGACTTGGCCCCCA CAGAGAGAGGTCCTACAGCTGTCATAAATTAAATTTATTCTCTGGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Product Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. |
Reference Data | |
RefSeq | NM_001146203.2 |
Summary | The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] |
Locus ID | 115727 |
MW | 37.3 |
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