AMACR Mouse Monoclonal Antibody [Clone ID: OTI3E10]
AMACR mouse monoclonal antibody, clone OTI3E10 (formerly 3E10)
Product Datasheet for 'TA808476'
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|Recommend Dilution||IHC 1:150|
|Immunogen||Full length human recombinant protein of human AMACR (NP_055139) produced in HEK293T cell.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from cell culture supernatant by affinity chromatography|
|Predicted Protein Size||42.2 kDa|
|Gene Name||alpha-methylacyl-CoA racemase|
|Background||This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]|
|Synonyms||AMACRD; CBAS4; RACE; RM|
|Protein Families||Druggable Genome|
|Protein Pathways||Metabolic pathways, Primary bile acid biosynthesis|