AMACR (NM_014324) Human Recombinant Protein

CAT#: TP313437

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Recombinant protein of human alpha-methylacyl-CoA racemase (AMACR), transcript variant 1


 Product Datasheet for 'TP313437'

 Cited in 1 publication.

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USD 748.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human alpha-methylacyl-CoA racemase (AMACR), transcript variant 1
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 42.2 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity ELISA capture for autoantibodies (PMID: 28191285)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_055139
Locus ID 23600
Refseq Size 2534
Cytogenetics 5p13.2
Refseq ORF 1385
Synonyms AMACRD; CBAS4; P504S; RACE; RM
Summary This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
Protein Families Druggable Genome
Protein Pathways Metabolic pathways, Primary bile acid biosynthesis

Citations (1)

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