AMACR (NM_014324) Human Recombinant Protein

CAT#: TP313437

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Recombinant protein of human alpha-methylacyl-CoA racemase (AMACR), transcript variant 1


Product Datasheet for 'TP313437'


 Cited in 1 publication.

  View other "AMACR" proteins (10)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human alpha-methylacyl-CoA racemase (AMACR), transcript variant 1
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC213437. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 42.2 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity ELISA capture for autoantibodies (PMID: 28191285)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_055139
Locus ID 23600
Refseq Size 2534
Cytogenetics 5p13.2
Refseq ORF 1385
Synonyms AMACRD; CBAS4; P504S; RACE; RM
Summary This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
Protein Families Druggable Genome
Protein Pathways Metabolic pathways, Primary bile acid biosynthesis

Citations (1)

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