H3FA (HIST1H3A) Rabbit Polyclonal Antibody

CAT#: TA347170

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Rabbit Polyclonal H3K27me3S28p Antibody


 Product Datasheet for 'TA347170'

USD 395.00


Availability*
5 Days

Size
    • 100 ul


Specifications

Product Data
Applications Assay, Dot, ELISA, IF, IP, WB
Recommend Dilution ChIP (1 µl/ChIP); ELISA (1:100 ?? 1:500); Dot blotting (1:20,000); Western blotting (1:250 - 1:500); Immunofluorescence (1:200); Immunoprecipitation (5 µl/IP)
Reactivity Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-H3K27me3S28p antibody: histone H3 containing the trimethylated lysine 27 and the phosphorylated serine 28 (H3K27me3S28p), using a KLH-conjugated synthetic peptide.
Concentration not determined
Purification Whole antiserum from rabbit containing 0.05% azide.
Gene Name histone cluster 1, H3a
Background Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called "histone code". Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. Phosphorylation of H3 on serine 28 is increased during mitosis.
Synonyms H3/A; H3FA
Reference Data
Protein Pathways Systemic lupus erythematosus
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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