AKT1 Mouse Monoclonal Antibody [Clone ID: 3B11-G8-B1]

CAT#: TA346876

Mouse Monoclonal AKT(pan) Antibody

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 Product Datasheet for 'TA346876'

USD 335.00


Availability*
3 Weeks

Size
    • 100 ul

Product images

Specifications

Product Data
Clone Name 3B11-G8-B1
Applications WB, IP
Recommend Dilution WB: 1:1000
Reactivity H,M,R
Host Mouse
Clonality Monoclonal
Immunogen The immunogen for AKT antibody: purified recombinant human AKT1 protein fragments expressed in E.coli.
Isotype IgG1
Formulation Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Reconstitution Method Reconstitute with PBS (pH7.3). To use this carrier-free antibody for conjugation experiment, we strongly recommend you to perform another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Affinity purified
Predicted Protein Size 60kDa
Gene Name AKT serine/threonine kinase 1
Background Akt1 is involved in cellular survival pathways,by inhibiting apoptotic processes.Akt1 is also able to induce protein synthesis pathways,and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth.Since it can block apoptosis,and thereby promote cell survival,Akt1 has been implicated as a major factor in many types of cancer.Akt(now also called Akt1)was originally identified as the oncogene in the transforming retrovirus,AKT8. Akt2 is an important signaling molecule in the Insulin signaling pathway.It is required to induce glucose transport.In a mouse which is for Akt1 but normal for Akt2,glucose homeostasis is unperturbed,but the animals are smaller,consistent with a role for Akt1 in growth.In contrast,mice which do not have Akt2,but have normal Akt1,have mild growth deficiency and display a diabetic phenotype(insulin resistance),again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. The role of Akt3 is less clear,though it appears to be predominantly expressed in the brain.It has been reported that mice lacking Akt3 have small brains.
Synonyms AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA
Reference Data
Protein Families Protein Kinase, ES Cell Differentiation/IPS, Druggable Genome
Protein Pathways MAPK signaling pathway, ErbB signaling pathway, Chemokine signaling pathway, mTOR signaling pathway, Apoptosis, VEGF signaling pathway, Focal adhesion, Tight junction, Toll-like receptor signaling pathway, Jak-STAT signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Neurotrophin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Adipocytokine signaling pathway, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.