Neurofilament (NEFL) Mouse Monoclonal Antibody [Clone ID: DA2]

USD 395.00


Availability*
2 Weeks

Size
    • 50 ul


Product images

Specifications

Product Data
Clone Name DA2
Applications IF, WB
Recommend Dilution WB: 1:5000-1:10000, IF: 1:100-1:500, IHC: 1:250
Reactivity Human, Mammalian, Mouse, Rat, Avian
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Native Neurofilament Light protein purified from pig spinal cord [UniProt# P02547]
Formulation Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration This product is unpurified. The exact concentration of antibody is not quantifiable.
Purification Ascites
Gene Name neurofilament, light polypeptide
Background Neuronal intermediate filaments or neurofilaments are found specifically in neurons where they play a key role in maintaining neuronal morphology as well as in regenerating myelinated axons. Neurofilaments contain three subunits: a light polypeptide (NEFL/NFL), a medium polypeptide (NEFM/NFM), and a heavy polypeptide (NEFH/NFH), with molecular weights of 68, 160, and 212 kD respectively. 68kD Neurofilament Light (NEFL) is the most abundant of three neurofilament proteins and, like other nonepithelial intermediate filament proteins, it can form homopolymeric 10-nm filaments. NEFL forms the backbone of neurofilament and perturbations in its expression leads to motor neuron diseases, such as Charcot-Marie-Tooth disease, type 2E (CMT2E). In addition to its influence on the nervous system, NEFL has been shown to act as a tumor suppressor and has been linked to carcinogenesis/metastasis of several malignancues including breast, prostate, lung, colon, and bladder cancer.
Synonyms CMT1F; CMT2E; NF-L; NF68; NFL; PPP1R110
Note This 68kDa Neurofilament Light antibody is useful in Immunocytochemistry/Immunofluorescence, Immunohistochemistry and Western blot.
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways Amyotrophic lateral sclerosis (ALS)

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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