GLI2 (NM_005270) Human Recombinant Protein

CAT#: TP761920

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Purified recombinant protein of Human GLI family zinc finger 2 (GLI2), Ala336-Leu709, with N-terminal HIS tag, expressed in E. coli, 50ug



  View other "GLI2" proteins (2)

USD 215.00


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    • 50 ug


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Product Data
Description Purified recombinant protein of Human GLI family zinc finger 2 (GLI2), Ala336-Leu709, with N-terminal HIS tag, expressed in E. coli, 50ug
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding the region(Ala336-Leu709) of GLI2
Tag N-His
Predicted MW 40.8 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0,150 mM NaCl, 10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_005261
Locus ID 2736
Refseq Size 6549
Cytogenetics 2q14.2
Refseq ORF 4758
Synonyms CJS; HPE9; PHS2; THP1; THP2
Summary This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS
Protein Pathways Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

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