PIAS2 (NM_004671) Human Recombinant Protein

CAT#: TP760271

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Recombinant protein of human protein inhibitor of activated STAT, 2 (PIAS2), transcript variant beta, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug


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USD 205.00


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    • 50 ug


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Product Data
Description Recombinant protein of human protein inhibitor of activated STAT, 2 (PIAS2), transcript variant beta, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Species Human
Expression Host E. coli
Tag N-His
Predicted MW 68.1 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Reference Data
RefSeq NP_004662
Locus ID 9063
Refseq Size 2360
Cytogenetics 18q21.1
Refseq ORF 1863
Synonyms ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4
Summary This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
Protein Families Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
Protein Pathways Jak-STAT signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis

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