IL1 beta (IL1B) (NM_000576) Human Recombinant Protein

CAT#: TP750014

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Recombinant protein of human IL 1 beta (IL1B) produced in E. coli.



  View other "IL1B" proteins (8)

USD 425.00


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    • 100 ug


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Specifications

Product Data
Description Recombinant protein of human IL 1 beta (IL1B) produced in E. coli.
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding the region (Ala117-Ser269) of human IL 1 beta
Tag Tag Free
Predicted MW 17.5 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a sterile solution containing 20 mM phosphate buffer, pH7.4.
Bioactivity Measured in a cell proliferation assay using D10S cell. ED50 for this effect is typically 2.1 - 3.2 ng/ml.
Endotoxin < 0.1 EU per 1 µg of the protein by the LAL
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000567
Locus ID 3553
Refseq Size 1498
Cytogenetics 2q14.1
Refseq ORF 807
Synonyms IL-1; IL1-BETA; IL1F2
Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diabetes mellitus

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