IL2 (NM_000586) Human Recombinant Protein

CAT#: TP720012

Recombinant protein of human interleukin 2 (IL2), Pro22-Thr153

Product images

Specifications

Product Data

• Description: Recombinant protein of human interleukin 2 (IL2), Pro22-Thr153
• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC210013, encoding the mature peptide (Pro22-Thr153) of human IL2
• Tag: Tag Free
• Predicted MW: 15.5 kDa
• Concentration: Resuspend the protein to the desired concentration in proper buffer.
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 µM filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0.
• Bioactivity: ED50 is less than 0.1 ng/ml as determined by the dose-dependent stimulation of murine CTLL-2 cells. Specific Activity of 1.0 x 107 IU/ mg.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Store at -80°C.
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_000577
• Locus ID: 3558
• Refseq Size: 822
• Cytogenetics: 4q27
• Refseq ORF: 459
• Synonyms: IL-2; lymphokine; TCGF
• Summary: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus