IL2 (NM_000586) Human Recombinant Protein

CAT#: TP720012

Recombinant protein of human interleukin 2 (IL2), Pro22-Thr153

Product images

Specifications

Product Data

• Description: Recombinant protein of human interleukin 2 (IL2), Pro22-Thr153
• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC210013, encoding the mature peptide (Pro22-Thr153) of human IL2
• Tag: Tag Free
• Predicted MW: 15.5 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 µM filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0.
• Bioactivity: ED50 is less than 0.1 ng/ml as determined by the dose-dependent stimulation of murine CTLL-2 cells. Specific Activity of 1.0 x 107 IU/ mg.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Store at -80°C.
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_000577
• Locus ID: 3558
• UniProt ID: P60568, Q0GK43
• Cytogenetics: 4q27
• Refseq Size: 822
• Refseq ORF: 459
• Synonyms: IL-2; lymphokine; TCGF
• Summary: This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus