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Flt3 ligand Human Protein

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SKU
DA3543X
Flt3 ligand human protein, 50 µg
Size:
50 ug
  $955.00
2 Weeks*
Bulk/Customize

Other products for "FLT3LG or NM_001204502"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGG LWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP P SCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSS TLP PPWSPRPLEA TAPTA
Predicted MW 17.6 kDa
Purity >98% by RP-HPLC, Anion-exchange FPLC, Silverstain
Presentation State Purified
Buffer Presentation State: Purified
State: Lyophilized (freeze-dried) without stabilizer
Bioactivity Biological: Human rh Flt3-ligand is fully biologically active when compared to standards.
The ED50 range is 0.5-1.0 ng/ml corresponding to a specific activity of 1-2MUnits/mg, calculated by the dose-dependant stimulation of the proliferation of Human OCMI-AML5 cells.
Endotoxin < 0.1 ng per µg (IEU/µg) of rh Flt3-Ligand
Reconstitution Method Recombinant Flt3-Ligand is soluble in water and most aqueous buffers.
Restore in water to a concentration not less than 0.1 mg/ml.
This solution can then be stored at 2-8°C for future use or diluted into other buffered solutions. Further dilutions should be made into buffer containing carrier protein or medium containing serum.
Preparation Lyophilized (freeze-dried) without stabilizer
Protein Description Flt3-ligand produced in E. coli is a soluble non-glycosylated 17.6 kDa polypeptide containing 155 amino acid residues which comprises the extracellular domain of the transmembrane flt3-ligand protein.
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Reference Data
RefSeq NP_001191431
Locus ID 2323
UniProt ID P49771
Cytogenetics 19q13.33
Synonyms SL cytokine, FLT3LG, Flt3L
Summary Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 PubMed 20933441).supplied by OMIM, Jan 2011
Protein Categories Cytokines, Intracellular Proteins, Membrane Proteins, Secreated Proteins
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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