VAV1 (NM_005428) Human Mass Spec Standard

CAT#: PH324806

VAV1 MS Standard C13 and N15-labeled recombinant protein (NP_005419)

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USD 1,995.00

3 Weeks

    • 10 ug

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Product Data
Description VAV1 MS Standard C13 and N15-labeled recombinant protein (NP_005419)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC224806
Predicted MW 98.1 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration 50 ug/ml as determined by BCA
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 100 mM glycine, 25 mM Tris-HCl, pH 7.3. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_005419
RefSeq Size 2888
RefSeq ORF 2535
Synonyms VAV; VAV
Locus ID 7409
Cytogenetics 19p13.3
Summary This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].
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