Insulin Receptor R (INSRR) (NM_014215) Human Untagged Clone

CAT#: SC315340

INSRR (untagged)-Human insulin receptor-related receptor (INSRR)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Insulin Receptor R
• Synonyms: IRR
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >SC315340 representing NM_014215.
  Blue=Insert sequence Red=Cloning site Green=Tag(s)
  
  GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
  GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
  ATGGCAGTGCCTAGTCTGTGGCCCTGGGGAGCATGCCTGCCTGTGATCTTCCTCTCCTTGGGATTTGGC
  CTGGATACAGTAGAGGTGTGCCCCAGCCTGGATATTCGCTCAGAGGTGGCAGAGCTTCGTCAGCTGGAG
  AACTGCAGCGTGGTGGAGGGCCACCTGCAGATCCTGCTCATGTTCACAGCCACCGGGGAGGACTTCCGC
  GGCCTCAGCTTCCCTCGCCTCACCCAGGTCACCGACTACCTGCTGCTCTTCCGTGTCTACGGACTGGAG
  AGCCTGCGCGACCTCTTCCCCAACCTAGCAGTCATCCGCGGGACGCGCCTCTTCCTGGGCTATGCACTG
  GTCATCTTTGAGATGCCACATCTGCGTGACGTGGCACTGCCTGCACTTGGGGCCGTGCTGCGTGGGGCT
  GTGCGTGTGGAGAAGAACCAGGAGCTCTGCCACCTCTCCACCATTGACTGGGGACTGCTGCAGCCAGCA
  CCTGGCGCCAACCACATCGTGGGCAACAAGCTGGGCGAGGAGTGTGCTGACGTGTGCCCTGGTGTGCTG
  GGTGCTGCTGGTGAGCCCTGTGCCAAGACCACCTTCAGCGGGCACACTGACTACAGATGCTGGACCTCC
  AGCCACTGCCAGAGAGTGTGCCCCTGCCCCCATGGGATGGCTTGCACAGCGAGGGGCGAGTGCTGCCAC
  ACCGAATGCCTGGGGGGCTGCAGCCAGCCAGAAGACCCTCGTGCCTGTGTAGCTTGCCGCCACCTCTAC
  TTCCAGGGTGCCTGCCTGTGGGCCTGCCCGCCAGGCACCTACCAGTATGAGTCCTGGCGCTGTGTCACA
  GCTGAGCGCTGTGCCAGCCTGCACTCTGTGCCCGGCCGTGCCTCCACCTTCGGCATACACCAGGGCAGT
  TGCCTGGCCCAGTGCCCTTCTGGCTTCACCCGTAATAGCAGCAGCATATTCTGCCACAAGTGCGAGGGG
  CTGTGCCCTAAAGAGTGCAAGGTAGGCACCAAGACCATCGACTCCATCCAGGCGGCACAGGATCTTGTG
  GGCTGCACGCATGTGGAGGGAAGCCTCATCCTCAACCTTCGCCAGGGCTACAACCTGGAGCCACAGCTG
  CAGCACAGCCTGGGGCTGGTAGAAACCATTACTGGCTTCCTCAAAATCAAGCACTCCTTTGCCCTCGTG
  TCCCTGGGCTTTTTCAAGAACCTCAAACTAATCCGGGGAGACGCCATGGTGGATGGGAACTACACTCTC
  TACGTGCTGGACAACCAGAACCTACAACAGCTAGGGTCCTGGGTGGCCGCGGGGCTCACCATTCCCGTG
  GGCAAGATCTACTTCGCCTTCAACCCGCGCCTCTGCTTGGAACACATCTACCGACTGGAGGAGGTGACA
  GGCACGCGAGGTCGGCAGAACAAGGCTGAGATCAACCCCCGCACCAACGGAGACCGCGCCGCCTGCCAG
  ACTCGCACCCTGCGCTTCGTGTCCAACGTGACGGAGGCAGACCGCATCCTGCTACGCTGGGAGCGCTAT
  GAGCCACTGGAGGCCCGCGACCTGCTCAGCTTCATCGTGTACTACAAGGAGTCCCCATTCCAGAACGCC
  ACAGAGCACGTGGGTCCAGATGCTTGTGGAACCCAGAGCTGGAACCTGCTGGATGTGGAGCTGCCCCTA
  AGCCGCACCCAGGAGCCAGGGGTGACCCTAGCCTCCCTCAAGCCTTGGACACAGTACGCAGTGTTTGTG
  CGGGCCATCACGCTAACCACTGAGGAGGACAGCCCTCATCAAGGAGCCCAGAGTCCCATCGTCTACCTC
  CGAACGCTGCCTGCAGCTCCCACGGTGCCCCAAGACGTCATCTCCACGTCCAACTCCTCCTCCCACCTC
  CTGGTGCGCTGGAAGCCACCGACCCAGCGCAATGGGAACCTCACCTACTACCTGGTGCTGTGGCAGCGG
  CTGGCAGAGGACGGCGACCTCTACCTCAATGACTACTGCCACCGCGGCTTGCGGCTGCCCACCAGCAAC
  AACGATCCGCGCTTCGACGGCGAAGACGGGGATCCTGAGGCCGAGATGGAGTCCGACTGCTGCCCTTGC
  CAGCACCCACCTCCTGGTCAGGTTCTGCCCCCGCTGGAGGCGCAAGAGGCCTCGTTCCAGAAGAAGTTT
  GAAAACTTTCTACACAACGCGATCACCATCCCCATATCCCCTTGGAAGGTGACGTCCATCAACAAGAGC
  CCCCAAAGGGACTCAGGGCGGCACCGCCGGGCAGCTGGGCCCCTCCGGCTGGGGGGCAACAGCTCGGAT
  TTCGAGATCCAGGAGGACAAGGTGCCCCGTGAGCGAGCGGTGCTGAGCGGCCTGCGCCACTTCACGGAA
  TACCGGATCGACATCCATGCCTGCAACCACGCGGCGCACACCGTGGGCTGCAGCGCCGCCACCTTCGTC
  TTTGCGCGCACCATGCCCCACAGAGAGGCTGATGGTATTCCAGGAAAGGTGGCCTGGGAGGCCTCCAGC
  AAGAACAGTGTCCTTCTGCGCTGGCTCGAGCCACCAGACCCCAACGGACTCATCCTCAAGTACGAAATC
  AAGTACCGCCGCTTGGGAGAGGAGGCCACAGTGCTGTGTGTGTCCCGTCTTCGATATGCGAAGTTTGGG
  GGAGTCCACCTGGCCCTGCTGCCCCCTGGAAACTACTCTGCCAGGGTTAGGGCAACCTCACTGGCTGGC
  AATGGCTCTTGGACAGACAGTGTTGCCTTCTACATCCTTGGCCCAGAGGAGGAGGATGCTGGGGGGCTG
  CATGTCCTCCTCACTGCCACCCCTGTGGGGCTCACGCTGCTCATCGTTCTTGCTGCCCTTGGTTTCTTC
  TACGGCAAGAAGAGAAACAGAACCCTGTATGCTTCTGTGAATCCAGAGTACTTCAGCGCCTCTGATATG
  TATGTCCCTGATGAATGGGAGGTGCCTCGGGAGCAGATCTCGATAATCCGGGAACTGGGCCAGGGCTCT
  TTTGGGATGGTATATGAGGGGCTGGCACGAGGACTTGAGGCTGGAGAGGAGTCCACACCCGTGGCCCTG
  AAGACGGTGAATGAGCTGGCCAGCCCACGGGAATGCATTGAGTTCCTCAAGGAAGCTTCTGTCATGAAA
  GCCTTCAAGTGTCACCATGTGGTGCGTCTCCTGGGTGTGGTATCTCAGGGCCAGCCAACTCTGGTCATC
  ATGGAGTTAATGACCCGTGGGGACCTCAAGAGCCATCTTCGATCTTTGCGGCCTGAGGCAGAGAACAAC
  CCTGGGCTCCCACAGCCAGCATTGGGGGAAATGATCCAAATGGCTGGTGAGATTGCAGACGGCATGGCC
  TACCTTGCTGCCAACAAGTTTGTGCACCGAGATCTAGCAGCCCGCAACTGCATGGTGTCCCAGGACTTC
  ACCGTCAAGATCGGGGACTTCGGGATGACTCGGGACGTGTATGAGACAGACTATTACCGCAAGGGTGGG
  AAGGGGCTGCTGCCCGTGCGCTGGATGGCCCCCGAGTCCCTCAAAGATGGGATCTTCACCACCCACTCG
  GATGTCTGGTCCTTTGGCGTGGTACTCTGGGAGATTGTGACCCTGGCAGAACAACCCTACCAGGGCCTG
  TCCAATGAGCAGGTGCTGAAGTTCGTCATGGATGGCGGGGTCCTGGAGGAGCTGGAGGGCTGTCCCCTT
  CAGCTGCAGGAGCTGATGAGCCGCTGCTGGCAGCCGAACCCACGCCTGCGCCCATCTTTCACACACATT
  CTGGACAGCATACAGGAGGAGCTGCGGCCCTCCTTCCGCCTCCTCTCCTTCTACTACAGCCCGGAATGC
  CGGGGGGCCCGGGGCTCCCTGCCTACCACCGATGCAGAGCCTGACTCCTCACCCACTCCAAGAGACTGC
  AGCCCTCAAAATGGGGGTCCAGGGCACTGA
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT
  TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_014215
• Insert Size: 3894 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_014215.2
• RefSeq Size: 4193 bp
• RefSeq ORF: 3894 bp
• Locus ID: 3645
• UniProt ID: P14616
• Cytogenetics: 1q23.1
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Prostate cancer, Regulation of actin cytoskeleton
• MW: 143.7 kDa
• Gene Summary: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.[UniProtKB/Swiss-Prot Function]