MTREX (NM_015360) Human Tagged ORF Clone

CAT#: RC206080

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SKIV2L2 (Myc-DDK-tagged)-Human superkiller viralicidic activity 2-like 2 (S. cerevisiae) (SKIV2L2)



Reconstitution Protocol

Special Offer: 20% off the control vector (empty cloning vector without insert). Use code "Shuttle20".

USD 118.00

USD 880.00


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Size
    • 10 ug


Product images

Specifications

Product Data
Type Human Tagged ORF Clone
Tag Myc-DDK
Symbol MTREX
Synonyms Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>RC206080 representing NM_015360
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCGGACGCATTCGGAGATGAGCTGTTCAGCGTGTTCGAGGGCGACTCGACCACTGCGGCGGGAACCA
AAAAAGACAAGGAAAAGGACAAGGGGAAATGGAAGGGGCCTCCAGGGTCTGCAGACAAGGCAGGGAAACG
TTTTGATGGTAAATTACAATCAGAATCAACTAATAATGGAAAAAATAAGAGAGATGTAGATTTCGAAGGT
ACAGATGAACCCATTTTTGGAAAGAAGCCCAGGATAGAAGAGTCAATAACTGAAGACTTAAGTTTGGCAG
ACCTGATGCCCAGAGTCAAGGTACAATCAGTTGAAACTGTTGAAGGGTGTACACATGAGGTTGCACTTCC
TGCAGAAGAGGATTATTTACCACTTAAACCACGAGTTGGAAAAGCTGCTAAGGAATACCCGTTCATTCTT
GATGCTTTTCAAAGAGAGGCCATTCAGTGTGTTGACAATAATCAGTCTGTTCTAGTATCTGCACATACCT
CAGCGGGAAAAACAGTATGCGCCGAGTATGCCATTGCATTGGCCTTAAGGGAAAAGCAGCGTGTAATATT
TACCAGCCCAATTAAGGCTCTGAGTAACCAAAAATACCGTGAAATGTATGAAGAATTTCAAGATGTTGGT
TTGATGACTGGTGATGTTACTATTAATCCTACGGCATCTTGTCTTGTTATGACCACAGAGATTTTGAGAA
GTATGCTTTACAGAGGTTCCGAAGTTATGAGAGAAGTTGCTTGGGTTATATTTGATGAAATTCATTATAT
GAGAGATTCAGAACGTGGTGTAGTATGGGAAGAAACTATTATTTTGCTTCCTGATAACGTCCACTATGTC
TTTCTTTCGGCTACTATTCCAAATGCCCGACAGTTTGCTGAATGGATTTGCCATTTACATAAACAGCCTT
GTCATGTTATTTACACAGATTATCGGCCCACTCCATTGCAACACTACATTTTTCCAGCAGGGGGAGATGG
CCTGCATCTTGTGGTTGATGAAAATGGTGACTTCAGAGAAGATAATTTTAATACTGCAATGCAAGTGCTT
CGAGATGCAGGTGATTTGGCCAAAGGAGACCAGAAAGGGCGGAAAGGAGGAACAAAAGGACCATCAAATG
TTTTCAAAATTGTGAAGATGATTATGGAAAGAAATTTCCAACCTGTGATTATTTTCAGTTTTAGTAAGAA
AGATTGTGAAGCCTATGCACTTCAAATGACCAAATTAGATTTCAACACAGATGAAGAAAAGAAGATGGTT
GAAGAAGTATTCAGTAATGCAATTGATTGCTTATCCGATGAAGATAAAAAACTCCCTCAGGTAGAACATG
TACTTCCTCTTTTGAAGAGGGGAATTGGTATTCACCATGGTGGTTTACTTCCTATTTTGAAAGAAACTAT
AGAAATTCTCTTTTCTGAAGGATTGATAAAGGCCTTATTTGCCACGGAGACCTTTGCTATGGGAATTAAC
ATGCCAGCTAGAACTGTTTTATTTACAAATGCCCGCAAATTTGATGGGAAGGATTTCCGATGGATTTCTT
CTGGTGAATACATTCAGATGTCTGGTCGTGCTGGAAGGAGAGGAATGGATGATAGAGGAATTGTAATTCT
TATGGTAGATGAAAAGATGAGCCCAACAATTGGAAAACAATTACTTAAGGGCTCCGCTGATCCTCTAAAT
AGTGCTTTCCATTTGACCTACAACATGGTTTTGAACTTACTACGTGTAGAAGAAATTAATCCTGAGTACA
TGTTGGAAAAATCCTTCTACCAGTTTCAGCATTATAGAGCAATTCCAGGAGTAGTAGAGAAGGTAAAGAA
TTCAGAAGAACAGTATAATAAAATAGTAATTCCCAATGAAGAAAGTGTGGTTATCTATTATAAGATTAGA
CAGCAGCTTGCCAAATTGGGTAAAGAAATTGAAGAATATATTCACAAACCAAAATACTGCTTACCTTTTC
TACAACCAGGTCGTTTGGTAAAGGTAAAGAATGAAGGAGATGACTTTGGCTGGGGAGTAGTGGTGAATTT
CTCAAAAAAGTCAAATGTTAAGCCTAACTCTGGTGAACTGGATCCTTTGTATGTAGTAGAAGTACTTCTG
CGCTGTAGCAAAGAGAGCTTGAAAAATTCAGCTACAGAAGCTGCAAAACCAGCTAAACCTGATGAGAAAG
GAGAGATGCAGGTTGTCCCAGTTTTGGTGCATCTCCTGTCTGCTATCAGCAGTGTTAGGCTTTACATTCC
TAAAGACCTTCGGCCGGTGGACAATAGACAGAGTGTTTTAAAATCAATACAGGAAGTTCAGAAACGTTTT
CCTGACGGCATCCCCTTATTAGACCCTATTGATGATATGGGCATTCAAGATCAAGGGCTGAAAAAAGTCA
TTCAGAAAGTAGAAGCTTTTGAGCATCGAATGTATTCTCATCCACTTCACAATGATCCAAATTTGGAAAC
TGTGTATACGCTTTGTGAAAAAAAAGCACAGATTGCAATAGATATTAAATCTGCAAAGCGAGAACTGAAG
AAAGCAAGAACAGTCCTACAAATGGATGAACTCAAATGTCGCAAACGTGTTTTAAGAAGGTTGGGATTTG
CTACTTCTTCTGATGTAATAGAGATGAAAGGACGAGTGGCTTGTGAGATAAGCAGTGCTGATGAGCTCCT
TCTAACTGAGATGATGTTTAATGGCCTTTTCAATGACCTTTCTGCAGAACAGGCAACAGCATTATTAAGC
TGCTTTGTGTTTCAAGAGAATTCTAGTGAGATGCCCAAATTAACAGAACAATTAGCAGGACCACTTCGTC
AAATGCAGGAATGTGCTAAAAGAATTGCAAAAGTTTCAGCAGAAGCCAAATTGGAAATTGATGAGGAAAC
TTATCTAAGCTCATTTAAACCTCACTTAATGGATGTAGTATATACCTGGGCAACTGGAGCTACATTTGCC
CATATCTGCAAAATGACAGATGTCTTTGAAGGCAGCATAATTCGTTGTATGAGGCGCCTGGAAGAATTGC
TTCGACAAATGTGTCAAGCAGCAAAAGCCATTGGAAACACTGAGCTGGAAAATAAATTTGCAGAAGGAAT
CACCAAAATCAAGAGAGATATTGTGTTTGCTGCCAGCCTCTACTTG


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAG
GTTTAA
>RC206080 representing NM_015360
Red=Cloning site Green=Tags(s)

MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEG
TDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFIL
DAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVG
LMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYV
FLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVL
RDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMV
EEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGIN
MPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLN
SAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESVVIYYKIR
QQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLL
RCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRF
PDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELK
KARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLS
CFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFA
HICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLYL

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Chromatograms CHROMATOGRAMS
Sequencher program is needed, download here.
Restriction Sites SgfI-MluI      Cloning Scheme for this gene      Plasmid Map     
ACCN NM_015360
ORF Size 3126 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_015360.5
RefSeq Size 4222 bp
RefSeq ORF 3129 bp
Locus ID 23517
UniProt ID P42285
Cytogenetics 5q11.2
Domains DEAD, helicase_C
Protein Pathways RNA degradation
MW 117.8 kDa
Gene Summary Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing.[UniProtKB/Swiss-Prot Function]
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