PTCH1 Mouse Monoclonal Antibody [Clone ID: OTI3C2]

CAT#: TA500122

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Anti-Patched1 (Patched) mouse monoclonal antibody, clone OTI3c2 (formerly 3c2)



  View other "OTI3C2" antibodies (2)

USD 379.00


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In Stock

Size
    • 100 ul


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Specifications

Product Data
Clone Name OTI3C2
Applications IF, WB
Recommended Dilution WB: 1:500, IF (1:100)
Reactivity Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Recombinant protein expressed in E.coli corresponding to amino acids 122-436 of human Patched1
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 160.4 kDa
Gene Name patched 1
Background This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
Synonyms BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

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