PTEN Mouse Monoclonal Antibody [Clone ID: A8A8]

CAT#: TA354759

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Mouse anti pTEN Monoclonal Antibody

USD 407.00

5 Days

    • 100 ug

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Product Data
Clone Name A8A8
Applications IHC, WB
Recommended Dilution WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG
Clonality Monoclonal
Immunogen A 403 aa of full length human pTEN recombinant protein.
Formulation This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size ~50 kDa
Gene Name phosphatase and tensin homolog
Background Thephosphatase and tensin homologue (PTEN) tumor suppressoris a phosphatidylionositol D3-phosphatase that contains the catalytic signature motif (HCXXGXXRS/T) found in all members of the protein tyrosine phosphatase family. PTEN is mutated in a wide range of cancers.In vitro, the recombinant PTEN can be regulated by phosphorylation on multiple serine and threonine residues in its C-terminus, such as CK2, GSK3beta at Ser-362, 370 and 385. It antagonizes signal transduction downstream of PI-3 kinases affecting cell proliferation, apoptosis and migration. Loss-of-function mutations in the PTEN gene lead to constitutive activation of multiple signaling pathways.
Synonyms 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Reference Data
Protein Families Druggable Genome, Phosphatase
Protein Pathways Endometrial cancer, Focal adhesion, Glioma, Inositol phosphate metabolism, Melanoma, p53 signaling pathway, Pathways in cancer, Phosphatidylinositol signaling system, Prostate cancer, Small cell lung cancer, Tight junction
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