BCAR3 Rabbit Polyclonal Antibody
Frequently bought together (3)
Recombinant protein of human breast cancer anti-estrogen resistance 3 (BCAR3), 20 µg
USD 867.00
Transient overexpression lysate of breast cancer anti-estrogen resistance 3 (BCAR3)
USD 436.00
Other products for "BCAR3"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml |
Reactivities | Human, Rat, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | A synthetic peptide derived from C-terminus of human BCAR3 protein. This sequence is identical to human, rat, mouse, canis and bovine. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 93 kDa |
Gene Name | breast cancer anti-estrogen resistance 3 |
Database Link | |
Background | Breast cancer anti-estrogen resistance 3 (BCAR3) is a also known as AND-34/BCAR3/NSP2 (BCAR3). Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. BCAR3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48 |
Synonyms | NSP2; SH2D3B |
Reference Data | |
Protein Families | Druggable Genome |
Documents
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in shipping.