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CARD15 (NOD2) Rabbit Polyclonal Antibody
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Specifications
| Product Data | |
| Applications | IHC |
| Recommended Dilution | IHC: 50-200 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivities | Human |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human NOD2 |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Gene Name | nucleotide binding oligomerization domain containing 2 |
| Database Link | |
| Background | This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. |
| Synonyms | ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | NOD-like receptor signaling pathway |
Documents
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| FAQs |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.