PML Protein (PML) Rabbit Polyclonal Antibody

CAT#: TA347266

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Rabbit Polyclonal PML Antibody

Product Datasheet for 'TA347266'

USD 315.00

5 Days

    • 50 ug

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Product Data
Applications ELISA, WB
Recommended Dilution ELISA (1:100 ?? 1:200); Western blotting (1:750)
Reactivity Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-PML antibody: human PML (Promyelocytic leukemia), using 3 different KLH-conjugated synthetic peptides.
Concentration 0.14 ug/ul
Purification Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name promyelocytic leukemia
Background PML (UniProtKB/Swiss-Prot entry P29590) is a transcription factor and tumor supressor which belongs to the tripartite motif (TRIM) family. This motif contains three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML regulates the response of p53 to oncogenic signals. It is often involved in a chromosomal translocation between chromosomes 15 and 17 which results in a PML/RARalpha fusion protein and is associated with most cases of acute promyelocytic leukemia.
Synonyms MYL; PP8675; RNF71; TRIM19
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis
Frequently bought together (3)
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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 159.00

Customer Reviews 
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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