TLR4 Mouse Monoclonal Antibody [Clone ID: 76B357.1]

CAT#: TA336410

Mouse Monoclonal TLR4 Antibody (76B357.1)

USD 605.00

2 Weeks*

    • 100 ug

Frequently bought together (3)
Transient overexpression lysate of toll-like receptor 4 (TLR4), transcript variant 1
    • 100 ug

USD 665.00

beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 200.00

Recombinant protein of human toll-like receptor 4 (TLR4), transcript variant 1, 20 µg
    • 20 ug

USD 867.00

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Product Data
Clone Name 76B357.1
Applications Block/Neutralize, ChIP, CyTOF-ready, Dot, ELISA, FC, ICC/IF, IHC, SDS-PAGE, WB
Recommended Dilution SDS-Page, Knockdown Validated, Dot Blot, Flow (Cell Surface), Flow (Intracellular), Flow Cytometry, ELISA, Block/Neutralize, Knockout Validated, Chromatin Immunoprecipitation (ChIP): 1:10-1:500, In vitro assay, ELISA Capture (Matched Antibody Pair): 0.5 ug, Western Blot: 1-3 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunohistochemistry: 1:10-1:500, Immunohistochemistry-Paraffin: 5 ug/ml, Immunohistochemistry-Frozen: 1:500, CyTOF-ready, Dual RNAscope ISH-IHC
Reactivities Human, Mouse, Rat, Squirrel
Host Mouse
Isotype IgG2b, kappa
Clonality Monoclonal
Immunogen This antibody was developed against a portion of amino acids 100-200 of human TLR4 (NP_612564).
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name toll like receptor 4
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The TLR4 cDNA codes for a protein consisting of 799 amino acids with approximate molecular weight of 88 kDa (6).
Synonyms ARMD10; CD284; TLR-4; TOLL
Note Flow (Intracellular) use reported in literature (See Cohen et al, 2008); Immunofluorescence (See Nowicki et al, 2009); IHC-F (Nowicki et al, 2012); Flow (cell surface) use reported in scientific literature (PMID 23796194)
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.