TRPV4 Rabbit Polyclonal Antibody
Rabbit Polyclonal TRPV4 Antibody
Product Datasheet for 'TA326707'
|Applications||IF, IHC, WB|
|Recommend Dilution||WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL|
|Immunogen||TRPV4 antibody was raised against an 18 amino acid peptide near the center of human TRPV4. The immunogen is located within amino acids 380 - 430 of TRPV4.|
|Formulation||TRPV4 antibody is supplied in PBS containing 0.02% sodium azide.|
|Purification||TRPV4 antibody is affinity chromatography purified via peptide column.|
|Predicted Protein Size||Predicted: 96 kDa; Observed: 110 kDa|
|Gene Name||transient receptor potential cation channel subfamily V member 4|
|Background||The transient receptor potential (TRP) protein family consists of a diverse group of cation channels functioning in a variety of homeostatic and regulatory pathways. Four subfamilies exist, based on channel domain homology: C type (canonical), V type (vanilloid receptor related), M type (melastatin related) and P type (PKD) (1). TRPV4, belongs to the V type subfamily and plays a role in systemic osmoregulation (2,3). TRPV4 is a calcium channel multi-pass membrane protein activated by various stimuli, including thermal stress, fatty acid metabolites and hypotonicity (3). TRPV4 is highly expressed in lung and kidney and widely expressed in brain. It plays an important role in regulating neural excitability (4).|
|Synonyms||BCYM3; CMT2C; HMSN2C; OTRPC4; SMAL; SPSMA; SSQTL1; TRP12; VRL2; VROAC|
|Protein Families||Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.