ABH2 (ALKBH2) Rabbit Polyclonal Antibody

CAT#: TA321252

Anti-ALKBH2 Rabbit Polyclonal Antibody

Product Images

Gel: 12%SDS-PAGE Lysate: 40 μg Lane 1-3: Human fetal liver tissue Human seminoma tissue RAW264.7 cells Primary antibody: TA321252 (ALKBH2 Antibody) at dilution 1/650 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 2 minutes

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human fetal liver and seminoma tissue, RAW264.7 cells
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 29 kDa
• Gene Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
• Database Link:
  NP_001001655
  Entrez Gene 231642 MouseEntrez Gene 121642 Human
  UniProt ID Q6NS38
• Background: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen; alpha-ketoglutarate and iron.
• Synonyms: ABH2

Reference Data

• Protein Families: Druggable Genome