TRIM5 alpha (TRIM5) Rabbit Polyclonal Antibody

CAT#: TA306150

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Rabbit Polyclonal TRIM5 gamma Antibody

USD 440.00

5 Days

    • 100 ug

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Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 2 ug/mL, ICC: 2 ug/mL, IF: 20 ug/mL
Reactivity Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen TRIM5 gamma antibody was raised against a synthetic peptide corresponding to 15 amino acids near the carboxy-terminus of human TRIM5 gamma.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name tripartite motif containing 5
Background TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region (1). TRIM5 has five alternately spliced isoforms, the longest of which is the ? variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). While a function has not yet been assigned to TRIM5gamma, it is known that expression of TRIM5gamma variants from humans, rhesus monkeys, and African green monkeys enable resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. Furthermore, the TRIM5gamma isoform appears to serve as a scaffold for the assembly of endogenous BTBD1 and BTBD2 proteins and also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner (4).
Synonyms RNF88; TRIM5alpha
Reference Data
Protein Families Druggable Genome
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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