IL4R Rabbit Polyclonal Antibody
IL4R rabbit polyclonal antibody, Aff - Purified
|Recommended Dilution||Western Blot: 1/500-1/1000.
|Reactivity||Human, Mouse, Rat|
|Immunogen||Synthetic peptide, corresponding to amino acids 460-510 of Human IL-4Rα.|
|Specificity||This antibody detects endogenous levels of IL-4R-alpha protein. (region surrounding Gly493)|
|Formulation||Phosphate buffered saline (PBS), pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Preservative: 15 mM Sodium Azide
|Purification||Affinity Chromatography using epitope-specific immunogen|
|Storage||Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Predicted Protein Size||~88.0 kDa|
|Gene Name||Homo sapiens interleukin 4 receptor (IL4R), transcript variant 1|
|Background||IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.|
|Synonyms||Interleukin-4 receptor alpha chain, IL-4R-alpha, IL4RA, 582J2.1, IL4 Receptor alpha|
|Protein Families||Druggable Genome, Secreted Protein|
|Protein Pathways||Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.