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- MEK1 (33)
- BETA CATENIN (23)
- P53 (20)
- MEK3 (17)
- SH3PX1 (15)
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Knockout (KO) Validation
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Families
- Druggable Genome (863)
- Transmembrane (177)
- Transcription Factors (161)
- Protein Kinase (143)
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- Secreted Protein (43)
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- Stem cell relevant signaling - DSL/Notch pathway (8)
- Stem cell relevant signaling - JAK/STAT signaling pathway (7)
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- Ion Channels: Other (5)
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- Ion Channels: Potassium (3)
- Embryonic stem cells (2)
- Ion Channels: Transient receptor potential (2)
- Nuclear Hormone Receptor (2)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (1)
- Stem cell relevant signaling - Wnt Signaling pathway (1)
Pathways
- Pathways in cancer (167)
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- Endometrial cancer (130)
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- Neurotrophin signaling pathway (117)
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- Fc epsilon RI signaling pathway (105)
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- Non-small cell lung cancer (104)
- Pancreatic cancer (104)
- Melanoma (103)
- Glioma (101)
- T cell receptor signaling pathway (99)
- ErbB signaling pathway (98)
- Insulin signaling pathway (96)
- Regulation of actin cytoskeleton (93)
- Bladder cancer (91)
- Progesterone-mediated oocyte maturation (90)
- Renal cell carcinoma (86)
- Chemokine signaling pathway (85)
- GnRH signaling pathway (85)
- Acute myeloid leukemia (84)
- B cell receptor signaling pathway (84)
- VEGF signaling pathway (82)
- Fc gamma R-mediated phagocytosis (81)
- Melanogenesis (77)
- Gap junction (76)
- Natural killer cell mediated cytotoxicity (74)
- Prion diseases (61)
- Vascular smooth muscle contraction (61)
- Long-term depression (60)
- Long-term potentiation (60)
- Wnt signaling pathway (59)
- Amyotrophic lateral sclerosis (ALS) (54)
- Endocytosis (54)
- Apoptosis (53)
- Tight junction (52)
- Leukocyte transendothelial migration (51)
- Oocyte meiosis (50)
- Pathogenic Escherichia coli infection (49)
- Adherens junction (48)
- Basal cell carcinoma (46)
- Dorso-ventral axis formation (46)
- Huntington's disease (46)
- Cell cycle (43)
- Small cell lung cancer (43)
- mTOR signaling pathway (41)
- Alzheimer's disease (39)
- Cell adhesion molecules (CAMs) (35)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (34)
- Type II diabetes mellitus (34)
- p53 signaling pathway (34)
- Proteasome (30)
- Antigen processing and presentation (28)
- Parkinson's disease (28)
- Jak-STAT signaling pathway (27)
- Purine metabolism (26)
- Glycolysis / Gluconeogenesis (25)
- Valine (25)
- leucine and isoleucine degradation (25)
- Ubiquitin mediated proteolysis (24)
- Axon guidance (23)
- NOD-like receptor signaling pathway (22)
- Fatty acid metabolism (19)
- Hematopoietic cell lineage (19)
- Nucleotide excision repair (19)
- Epithelial cell signaling in Helicobacter pylori infection (18)
- Adipocytokine signaling pathway (16)
- Complement and coagulation cascades (16)
- Oxidative phosphorylation (16)
- Spliceosome (16)
- Systemic lupus erythematosus (16)
- Arginine and proline metabolism (14)
- Calcium signaling pathway (14)
- TGF-beta signaling pathway (14)
- Lysosome (13)
- Primary immunodeficiency (13)
- Tryptophan metabolism (13)
- Histidine metabolism (12)
- Phosphatidylinositol signaling system (12)
- Pyruvate metabolism (12)
- Fatty acid elongation in mitochondria (11)
- Glutathione metabolism (11)
- RIG-I-like receptor signaling pathway (11)
- RNA degradation (11)
- Type I diabetes mellitus (11)
- Alanine (10)
- Butanoate metabolism (10)
- Lysine degradation (10)
- One carbon pool by folate (10)
- Propanoate metabolism (10)
- Tyrosine metabolism (10)
- aspartate and glutamate metabolism (10)
- Base excision repair (9)
- Cysteine and methionine metabolism (9)
- Cytokine-cytokine receptor interaction (9)
- DNA replication (9)
- Homologous recombination (9)
- Metabolism of xenobiotics by cytochrome P450 (9)
- Pyrimidine metabolism (9)
- Vibrio cholerae infection (9)
- beta-Alanine metabolism (9)
- Drug metabolism - cytochrome P450 (8)
- Folate biosynthesis (8)
- Hypertrophic cardiomyopathy (HCM) (8)
- Mismatch repair (8)
- Neuroactive ligand-receptor interaction (8)
- Regulation of autophagy (8)
- Viral myocarditis (8)
- Dilated cardiomyopathy (7)
- Galactose metabolism (7)
- Glycine (7)
- Pentose phosphate pathway (7)
- Terpenoid backbone biosynthesis (7)
- serine and threonine metabolism (7)
- Citrate cycle (TCA cycle) (6)
- Selenoamino acid metabolism (6)
- Synthesis and degradation of ketone bodies (6)
- Amino sugar and nucleotide sugar metabolism (5)
- Arachidonic acid metabolism (5)
- Cardiac muscle contraction (5)
- Nitrogen metabolism (5)
- Notch signaling pathway (5)
- Renin-angiotensin system (5)
- Retinol metabolism (5)
- Allograft rejection (4)
- Fructose and mannose metabolism (4)
- Glycerolipid metabolism (4)
- Glycosaminoglycan degradation (4)
- Inositol phosphate metabolism (4)
- Methane metabolism (4)
- Non-homologous end-joining (4)
- Phenylalanine metabolism (4)
- Androgen and estrogen metabolism (3)
- Autoimmune thyroid disease (3)
- Basal transcription factors (3)
- Caffeine metabolism (3)
- Drug metabolism - other enzymes (3)
- Glycosphingolipid biosynthesis - ganglio series (3)
- Graft-versus-host disease (3)
- Hedgehog signaling pathway (3)
- N-Glycan biosynthesis (3)
- Other glycan degradation (3)
- Sphingolipid metabolism (3)
- Ascorbate and aldarate metabolism (2)
- Asthma (2)
- Glycerophospholipid metabolism (2)
- Limonene and pinene degradation (2)
- Maturity onset diabetes of the young (2)
- PPAR signaling pathway (2)
- RNA polymerase (2)
- Ribosome (2)
- SNARE interactions in vesicular transport (2)
- Starch and sucrose metabolism (2)
- Steroid biosynthesis (2)
- Aminoacyl-tRNA biosynthesis (1)
- Biosynthesis of unsaturated fatty acids (1)
- Cytosolic DNA-sensing pathway (1)
- D-Glutamine and D-glutamate metabolism (1)
- ECM-receptor interaction (1)
- Glyoxylate and dicarboxylate metabolism (1)
- Keratan sulfate biosynthesis (1)
- Pantothenate and CoA biosynthesis (1)
- Phenylalanine (1)
- Sulfur metabolism (1)
- Taste transduction (1)
- Taurine and hypotaurine metabolism (1)
- Vitamin B6 metabolism (1)
- tyrosine and tryptophan biosynthesis (1)