TARC (CCL17) (NM_002987) Human Recombinant Protein
CAT#: TP723729
Purified recombinant protein of Human chemokine (C-C motif) ligand 17 (CCL17 / TARC)
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Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
Human CCL17, the region of Ala24-Ser94, from gene Accession# NM_002987
|
Tag | Tag Free |
Predicted MW | 8.0 kDa |
Concentration | lot specific |
Purity | >98%, as determined by Coomassie stained SDS-PAGE. |
Buffer | 1 x PBS |
Bioactivity | Bioactivity was measured by its property to chemoattract Baf3-hCCR4 transfectans cells in a dose dependent manner. |
Endotoxin | Less than 0.01 ng per µg protein as determined by the LAL method |
Storage | Store at -80°C. |
Stability | Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
Reference Data | |
RefSeq | NP_002978 |
Locus ID | 6361 |
UniProt ID | Q92583 |
Cytogenetics | 16q21 |
Refseq Size | 615 |
Refseq ORF | 282 |
Synonyms | A-152E5.3; ABCD-2; SCYA17; TARC |
Summary | This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014] |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction |
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