IL15 (NM_000585) Human Recombinant Protein

CAT#: TP720014

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Recombinant protein of human interleukin 15 (IL15)


 Product Datasheet for 'TP720014'

  View other "IL15" proteins (8)

USD 299.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description Recombinant protein of human interleukin 15 (IL15)
Species Human
Expression Host E. coli
Tag Tag Free
Predicted MW 12.8 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.0.
Bioactivity ED50 is less than 0.5 ng/ml as determined by the dose dependent stimulation of mouse CTLL-2 cell proliferation. Specific Activity of 2.0 x 106 IU/mg.
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Reference Data
RefSeq NP_000576
Locus ID 3600
Refseq Size 2012
Cytogenetics 4q31.21
Refseq ORF 486
Synonyms IL-15
Summary The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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Other Versions

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    • 100 ug

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68 Mouse Clones
HUMAN PROREINS 101