CBLB (NM_170662) Human Recombinant Protein

CAT#: TP306047

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Recombinant protein of human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB)


 Product Datasheet for 'TP306047'

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USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 109.3 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_733762
Locus ID 868
Refseq Size 3976
Cytogenetics 3q13.11
Refseq ORF 2946
Synonyms Cbl-b; Nbla00127; RNF56
Summary This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
Protein Families Druggable Genome
Protein Pathways Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Ubiquitin mediated proteolysis

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