KEAP1 (NM_203500) Human Recombinant Protein
Recombinant protein of human kelch-like ECH-associated protein 1 (KEAP1), transcript variant 1
Product Datasheet for 'TP302189'
Specifications
Product Data | |
Description | Recombinant protein of human kelch-like ECH-associated protein 1 (KEAP1), transcript variant 1 |
Species | Human |
Expression Host | HEK293T |
Tag | C-Myc/DDK |
Predicted MW | 69.5 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Reference Data | |
RefSeq | NP_987096 |
Locus ID | 9817 |
Refseq Size | 2606 |
Cytogenetics | 19p13.2 |
Refseq ORF | 1872 |
Synonyms | INrf2; KLHL19 |
Summary | This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] |
Protein Families | Transcription Factors |
Protein Pathways | Ubiquitin mediated proteolysis |
Citations (2)
The use of this Proteins has been cited in the following citations: |
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Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo
,Chen, H;Fu, J;Chen, H;Hu, Y;Soroka, DN;Prigge, JR;Schmidt, EE;Yan, F;Major, MB;Chen, X;Sang, S;,
Chem. Res. Toxicol. Sep 2014
,PubMed ID 25148906
[KEAP1]
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Identification of UV-protective Activators of Nuclear Factor Erythroid-derived 2-Related Factor 2 (Nrf2) by Combining a Chemical Library Screen with Computer-based Virtual Screening
,Franziska Lieder, Felix Reisen, Tim Geppert, Gabriel Sollberger, Hans-Dietmar Beer, Ulrich auf dem Keller, Matthias Schäfer, Michael Detmar, Gisbert Schneider, and Sabine Werner,
J. Biol. Chem., Sep 2012; 287: 33001 - 33013.
[KEAP1]
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Documents
FAQs |
SDS |
Resources
Protein Resources |
Other Versions
SKU | Description | Size | Price |
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PH302189 | KEAP1 MS Standard C13 and N15-labeled recombinant protein (NP_987096) |
USD 1,995.00 |
|
PH302513 | KEAP1 MS Standard C13 and N15-labeled recombinant protein (NP_036421) |
USD 1,995.00 |
|
TP302513 | Recombinant protein of human kelch-like ECH-associated protein 1 (KEAP1), transcript variant 2 |
USD 748.00 |
|
LY404250 | Transient overexpression lysate of kelch-like ECH-associated protein 1 (KEAP1), transcript variant 1 |
USD 315.00 |
|
LY402183 | Transient overexpression lysate of kelch-like ECH-associated protein 1 (KEAP1), transcript variant 2 |
USD 315.00 |
|
LC810295 | KEAP1-knockout Cell lysate from HeLa cell ine, one vial of parental cell line lysate included as control |
USD 495.00 |
|
LC402183 | KEAP1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 95.00 |
|
LC404250 | KEAP1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 95.00 |
USD 299.00
USD 379.00