VHL (1-154, His-tag) Human Protein

CAT#: SA6057

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VHL (1-154, His-tag) human protein, 0.1 mg


Product Datasheet for 'SA6057'


USD 260.00


Availability*
2 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Description VHL (1-154, His-tag) human protein, 0.1 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MGSSHHHHHH SSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLP
Tag His-tag
Predicted MW 19 kDa
Concentration 1.0 mg/ml
Purity >95% > 95% by SDS PAGE
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: PBS, 1 mM DTT, 2mM EDTAI, pH 7.4
Preparation Liquid purified protein
Protein Description VHL beta-domain (1-154 aa), fused to HIs-tag, was overexpressed in E.coli and purified by using conventional chromatography techniques.
Storage

Store at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Reference Data
RefSeq NP_000542
Locus ID 7428
Cytogenetics 3p25.3
Synonyms HRCA1; pVHL; RCA1; VHL1
Summary Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis

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