Interleukin-2 / IL2

USD 260.00


Availability*
2 Weeks

Size
    • 50 ug


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Specifications

Product Data
Species Human
Expression Host E. coli
Predicted MW 15.4 kDa
Concentration Units/vial: 5 x 10e5 (DA3559x), 5 x 10e4 (DA3559)
Purity > 97 % > 98% by SDS-PAGE and Silver staining
Bioactivity > 1 x > 1 x = 1 x 10e7 units/mg The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is 0.1-0.5 ng/ml.
Endotoxin < 0.1 ng per µg of IL-2
Reconstitution 100 mM acetic acid to a concentration of 100 ng/ml. This solution can be diluted into other buffered solutions or stored at -20°C for future use.
Preparation Lyophilized protein, without buffer and stabilizer
Reference Data
RefSeq NP_000577
Locus ID 3558
Cytogenetics 4q27
Synonyms IL-2; lymphokine; TCGF
Summary The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus

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68 Mouse Clones