BMP2 / BMP2A (CHO cell derived)

CAT#: AR31188PU-N

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Recombinant Human BMP-2 derived from CHO cells is a homodimeric glycoprotein that consists of two 114 amino acid polypeptide chains linked by a single disulfide bond. Due to glycosylation, CHO cell-derived Human BMP-2 migrates at an apparent molecular weight of approximately 28-29 kDa by SDS-PAGE analysis under non-reducing conditions.
Mature sequence is complete identical with Mouse and Rat.


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USD 250.00


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2 Weeks

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    • 10 ug


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Product Data
Description Recombinant Human BMP-2 derived from CHO cells is a homodimeric glycoprotein that consists of two 114 amino acid polypeptide chains linked by a single disulfide bond. Due to glycosylation, CHO cell-derived Human BMP-2 migrates at an apparent molecular weight of approximately 28-29 kDa by SDS-PAGE analysis under non-reducing conditions.
Mature sequence is complete identical with Mouse and Rat.
Species Human
Expression Host CHO
Predicted MW 26.0 kDa
Purity > 95 % pure by SDS-PAGE gel and HPLC analyses.
Bioactivity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 40-100 ng/ml.
Endotoxin < 0.1 ng/µg (1EU/µg)
Reconstitution Restore in water to a concentration of 0.1-1.0 mg/ml.
This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use.
Preparation Lyophilized (sterile filtered) purified protein
Reference Data
RefSeq NP_001191
Locus ID 650
Cytogenetics 20p12.3
Synonyms BDA2; BMP2A
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane
Protein Pathways Basal cell carcinoma, Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, Pathways in cancer, TGF-beta signaling pathway

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68 Mouse Clones