Interleukin-1 alpha / IL-1A (113-271, His-tag) Human Protein
Interleukin-1 alpha / IL-1A (113-271, His-tag) human recombinant protein, 50 µg
|Expression Host||E. coli|
|Expression cDNA Clone or AA Sequence||
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSA PFSFLSNVKY NFMRIIKYEF ILNDALNQSI IRANDQYLTA AALHNLDEAV KFDMGAYKSS KDDAKITVIL RISKTQLYVT AQDEDQPVLL KEMPEIPKTI TGSETNLLFF WETHGTKNYF TSVAHPNLFI ATKQDYWVCL AGGPPSITDF QILENQA
|Predicted MW||22.4 kDa|
|Purity||>90% > 90% by SDS PAGE|
|Buffer||Presentation State: Purified
State: Liquid purified protein
Buffer System: 20 mM Tris-HCl pH 7.5, 10% glycerol
|Preparation||Liquid purified protein|
|Protein Description||Recombinant IL-1a protein, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Storage||Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Synonyms||IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1F1|
|Summary||The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]|
|Protein Families||Druggable Genome, Secreted Protein|
|Protein Pathways||Apoptosis, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, Prion diseases, Type I diabetes mellitus|
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