Insulin-like growth factor I / IGF1 Human Protein

CAT#: AR09044PU-N

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Insulin-like growth factor I / IGF1 human recombinant protein, 0.1 mg


Product Datasheet for 'AR09044PU-N'


USD 190.00


Availability*
2 Weeks

Size
    • 100 ug


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Specifications

Product Data
Description Insulin-like growth factor I / IGF1 human recombinant protein, 0.1 mg
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence MGPETLCGAE LVDALQFVCG DRGFYFNKPT GYGSSSRRAP QTGIVDECCF RSCDLRRLEM YCAPLKPAKS A
Predicted MW 7.7 kDa
Concentration 1 mg/ml (determined by Bradford assay)
Purity >95% pure by SDS-PAGE
Buffer Presentation State: Purified
State: Liquid purified protein
Buffer System: PBS, pH 7.4
Bioactivity Biological: The ED50 for this effect is < 3.6 ng/ml. Measured in a cell proliferation assay using MCF7 cell.
Preparation Liquid purified protein
Protein Description Recombinant Human IGF-1 was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Reference Data
RefSeq NP_000609
Locus ID 3479
Cytogenetics 12q23.2
Synonyms IGF; IGF-I; IGFI; MGF
Summary The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Dilated cardiomyopathy, Focal adhesion, Glioma, Hypertrophic cardiomyopathy (HCM), Long-term depression, Melanoma, mTOR signaling pathway, Oocyte meiosis, p53 signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer

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