Serglycin (SRGN) Human Gene Knockout Kit (CRISPR)

CAT#: KN202118LP

SRGN - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Donor DNA: Luciferase-Puro
• Symbol: Serglycin
• Locus ID: 5552
• Components:

  KN202118G1, Serglycin gRNA vector 1 in pCas-Guide CRISPR vector

  KN202118G2, Serglycin gRNA vector 2 in pCas-Guide CRISPR vector

  KN202118LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001321053, NM_001321054, NM_002727, NR_036430
• UniProt ID: P10124
• Synonyms: PPG; PRG; PRG1
• Summary: This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]