Human Serglycin (SRGN) activation kit by CRISPRa

CAT#: GA103748

SRGN CRISPRa kit - CRISPR gene activation of human serglycin

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: SRGN
• Locus ID: 5552
• Kit Components:

  GA103748G1, Serglycin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103748G2, Serglycin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103748G3, Serglycin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001321053, NM_001321054, NM_002727, NR_036430
• UniProt ID: P10124
• Synonyms: PPG; PRG; PRG1
• Summary: This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]