Human NSUN2 activation kit by CRISPRa

CAT#: GA110345

NSUN2 CRISPRa kit - CRISPR gene activation of human NOP2/Sun RNA methyltransferase 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: NSUN2
• Locus ID: 54888
• Kit Components:

  GA110345G1, NSUN2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110345G2, NSUN2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110345G3, NSUN2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001193455, NM_017755, NR_037947
• UniProt ID: Q08J23
• Synonyms: MISU; MRT5; SAKI; TRM4
• Summary: This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]