SMAD3 (NM_001145104) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC227712L4V

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  • LentiORF®

Lenti ORF particles, SMAD3 (mGFP-tagged)-Human SMAD family member 3 (SMAD3), transcript variant 4, 200ul, >10^7 TU/mL



USD 850.00


Availability*
11 Weeks

Size
    • 200 ul


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Specifications

Product Data
Product Name SMAD3 (NM_001145104) Human Tagged ORF Clone Lentiviral Particle
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Symbol SMAD3
Synonyms HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3
Vector pLenti-C-mGFP-P2A-Puro
ACCN NM_001145104
ORF Size 1278 bp
Sequence Data
The ORF insert of this clone is exactly the same as(RC227712).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_001145104.1, NP_001138576.1
RefSeq Size 5441 bp
RefSeq ORF 693 bp
Locus ID 4088
Cytogenetics 15q22.33
Protein Families Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors
Protein Pathways Adherens junction, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Pancreatic cancer, Pathways in cancer, TGF-beta signaling pathway, Wnt signaling pathway
MW 48.1 kDa
Gene Summary The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, Nov 2019]
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