CD105 (ENG) (NM_000118) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC221699L1V

Lenti ORF particles, ENG (Myc-DDK tagged) - Human endoglin (ENG), transcript variant 2, 200ul, >10^7 TU/mL

Product Images

RC221699L1 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC221699L1V particle to overexpress human ENG-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: CD105
• Synonyms: END; HHT1; ORW1
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_000118
• ORF Size: 1884 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC221699).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000118.1
• RefSeq Size: 3142 bp
• RefSeq ORF: 1878 bp
• Locus ID: 2022
• UniProt ID: P17813
• Cytogenetics: 9q34.11
• Domains: zona_pellucida
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• MW: 67.78 kDa
• Gene Summary: This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]